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Histrelin
CAS No. 76712-82-8
Histrelin( Supprelin LA )
Catalog No. M24769 CAS No. 76712-82-8
Histrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 77 | In Stock |
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| 5MG | 99 | In Stock |
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| 10MG | 166 | In Stock |
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| 25MG | 305 | In Stock |
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| 50MG | 448 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameHistrelin
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NoteResearch use only, not for human use.
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Brief DescriptionHistrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency.
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DescriptionHistrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency. It is considered a GnRH agonist. Histrelin is used in the treatment of hormone-sensitive cancers of the prostate in men and uterine fibroids in women.
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In VitroHistrelin (10-100 nM) stimulates the release of vasopressin (VP) from from isolated rat hypothalamo-neurohypophysial explants.Histrelin (100 nM) stimulates oxytocin (OT) release from the rat hypothalamo-neurohypophysial system.
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In VivoAnimal Model:Csfmop/Csfmop mice Dosage:0.001, 0.05, and 0.1 mg/kg Administration:Subcutaneous injection Result:Increased serum FSH concentrations by 4-fold.Animal Model:Rabbits Dosage:10, 30, or 100 μg /day Administration:Subcutaneous injection for 4 weeks Result:Caused a regression of the endometrial glands and a thinning of the stroma.
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SynonymsSupprelin LA
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number76712-82-8
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Formula Weight1323.5
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Molecular FormulaC66H86N18O12
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Purity>98% (HPLC)
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SolubilityDMSO:Soluble; Water:Insoluble
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SMILESCCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CN(C=N2)CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lewis KA, Goldyn AK, West KW, Eugster EA. A single histrelin implant is effective for 2 years for treatment of central precocious puberty. J Pediatr. 2013 Oct;163(4):1214-6. doi: 10.1016/j.jpeds.2013.05.033. Epub 2013 Jul 1. PubMed PMID: 23809043.
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