Histrelin( Supprelin LA )

Catalog No. M24769 CAS No. 76712-82-8

Histrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

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Biological Information

Product Name

Histrelin
Note

Research use only, not for human use.
Brief Description

Histrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency.
Description

Histrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency. It is considered a GnRH agonist. Histrelin is used in the treatment of hormone-sensitive cancers of the prostate in men and uterine fibroids in women.
In Vitro

Histrelin (10-100 nM) stimulates the release of vasopressin (VP) from from isolated rat hypothalamo-neurohypophysial explants.Histrelin (100 nM) stimulates oxytocin (OT) release from the rat hypothalamo-neurohypophysial system.
In Vivo

Animal Model:Csfmop/Csfmop mice Dosage:0.001, 0.05, and 0.1 mg/kg Administration:Subcutaneous injection Result:Increased serum FSH concentrations by 4-fold.Animal Model:Rabbits Dosage:10, 30, or 100 μg /day Administration:Subcutaneous injection for 4 weeks Result:Caused a regression of the endometrial glands and a thinning of the stroma.
Synonyms

Supprelin LA
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

76712-82-8
Formula Weight

1323.5
Molecular Formula

C66H86N18O12
Purity

>98% (HPLC)
Solubility

DMSO:Soluble; Water:Insoluble
SMILES

CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CN(C=N2)CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Lewis KA, Goldyn AK, West KW, Eugster EA. A single histrelin implant is effective for 2 years for treatment of central precocious puberty. J Pediatr. 2013 Oct;163(4):1214-6. doi: 10.1016/j.jpeds.2013.05.033. Epub 2013 Jul 1. PubMed PMID: 23809043.

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