Kahweol

Research use only, not for human use.

Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities.

Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibiting IkappaB kinase activity.

Kahweol (20-40 μM; 24 hours) decreases TGF-β-induced CTGF protein expression in AML12 and LX2 cells.Kahweol (20-40 μM; 1 hour) decreases TGF-β-induced phospho-Smad2/3 expression in AML12 cells, but does not affect expression in LX2 cells.Kahweol (20-40 μM) significantly decreased TGF-β-stimulated phospho-ERK and JNK expression in primary hepatocytes only.kahweol (0-25 μg/ml; 6-24 hours)increased the phosphorylation of AMPK and its downstream target Acetyl-CoA carboxylase (ACC) in a time-dependent manner in 3T3-L1 cells.kahweol (0-25 μg/ml) significantly affects protein expression of PPARγ, C/EBPα, FABP4, and FASN, that regulate adipocyte differentiation and lipid metabolism. Western Blot Analysis Cell Line:3T3-L1 cells Concentration:0, 5, 10, 25 μg/ml Incubation Time:Result:Reduced PPARγ, C/EBPα, FABP4, and FASN expression in a dose-dependent manner.

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Membrane Transporter/Ion Channel

AMPK

AMPK|Apoptosis|NF-Κb

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6894-43-5

314.42

C20H26O3

>98% (HPLC)

In Vitro:?DMSO : ≥ 33.33 mg/mL (106.00 )

C[C@]1([C@@H]2CC[C@](C3)(C4)[C@H]1CC[C@H]3[C@]4(CO)O)C=Cc1c2cco1

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(-20℃)

With Ice Pack

≥ 2 years