BC1618( 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- )

Catalog No. M24005 CAS No. 2222094-18-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BC1618
Note

Research use only, not for human use.
Brief Description

BC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling.
Description

BC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity.
In Vitro

Western Blot Analysis Cell Line:BEAS-2B cells.Concentration:0-2 μM.Incubation Time:16 h.Result:Induced pAmpkα and pACC protein levels dose-dependently.
In Vivo

Animal Model:C57BL/6 mice.Dosage:2 or 10 mg/kg (challenged with LPS (3 mg/kg) for an additional 18 h).Administration:IP, once.Result:Reduced lung inflammation in endotoxin treated mice.Animal Model:C57BL/6 mice.Dosage:15 and 30 mg/kg/d.Administration:Drinking water for 3 months.Result:Exhibited no obvious toxicity.
Synonyms

2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-
Pathway

Membrane Transporter/Ion Channel
Target

AMPK
Recptor

AMPK|E1/E2/E3 Enzyme|Fbxo48|Mitophagy
Research Area

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Indication

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1.Yuan Liu, et al. A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance. Nat Chem Biol. 2021 Mar;17(3):298-306.

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