D-Glutamic acid

CAS No. 6893-26-1

D-Glutamic acid( (R)-Glutamic acid )

Catalog No. M24704 CAS No. 6893-26-1

D-glutamic acid, the enantiomer of L-glutamic acid, is widely used in medicine and food.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    D-Glutamic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    D-glutamic acid, the enantiomer of L-glutamic acid, is widely used in medicine and food.
  • Description
    D-glutamic acid, the enantiomer of L-glutamic acid, is widely used in medicine and food.
  • In Vitro
    Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu) are widely found in mammals including human beings and they are now thought to be the candidates of novel physiologically active substances and/or biomarkers. D-[Asp/Glu] (4 mg/mL) inhibits IgE binding (75%) to peanuts while D-Glu, D-Asp has no inhibitory effect. IgE is specific for D-[Asp/Glu] and may have the potential for removing IgE or reducing IgE binding to peanut allergens.
  • In Vivo
    D-glutamic acid is currently paid attention as a modulator of neuronal transmission and hormonal secretion. It is metabolized only by D-aspartate oxidase in mammals. After intraperitoneal injection, L-glutamate is catabolized via a-ketoglutarate, whereas D-glutamate is converted to n-pyrrolidone carboxylic acid. Carbon 2 of both D- and L-glutamate is converted in the cecum to the methyl carbon of acetate. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid.
  • Synonyms
    (R)-Glutamic acid
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    Human Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6893-26-1
  • Formula Weight
    147.13
  • Molecular Formula
    C5H9NO4
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:10 mg/mL (67.97 mM; Need ultrasonic)
  • SMILES
    N[C@H](CCC(O)=O)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Han H, et al. Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities. J Pharm Biomed Anal. 2015 Dec 10;116:47-52.
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