Polygalacin D

Research use only, not for human use.

Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities.

Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxic effect on RAW 264.7 macrophages, and can suppress induction by LPS of pro-inflammatory cytokines such as prostaglandin E2 (PGE2).

Polygalacin D (0-40 μM; 48 hours) inhibits cell proliferation with IC50s of26.49 μM in the A549 cells and 20.52 μM in the H460 cells.Polygalacin D (0-20 μM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells.Polygalacin D (0-20 μM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells. Cell Proliferation Assay Cell Line:A549 and H460 cancer cell lines Concentration:10 μM, 20 μM, 40μM Incubation Time:48 hours Result:Inhibited the proliferation of NSCLC cell lines. Apoptosis Analysis Cell Line:A549 and H460 cancer cell lines Concentration:10 μM, 20 μM Incubation Time:48 hours Result:Induced apoptosis of NSCLC cell lines.Western Blot Analysis Cell Line:A549 and H460 cancer cell lines Concentration:10 μM, 20 μM Incubation Time:48 hours Result:Decreased survivin, c-IAP-1 and c-IAP-2 expression.

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Apoptosis

Apoptosis

Apoptosis|IAP

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66663-91-0

1209.4

C57H92O27

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (82.69 mM)

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(-20℃)

With Ice Pack

≥ 2 years