Cart
sales@molnova.com
Home - Products - Wnt/Notch/Hedgehog - Smoothened (Smo) - IHR-1

IHR-1

CAS No. 548779-60-8

IHR-1( —— )

Catalog No. M24536 CAS No. 548779-60-8

IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 61 In Stock
5MG 88 In Stock
10MG 128 In Stock
25MG 230 In Stock
50MG 327 In Stock
100MG 485 In Stock
500MG 1062 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    IHR-1
  • Note
    Research use only, not for human use.
  • Brief Description
    IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
  • Description
    IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Smoothened (Smo)
  • Recptor
    Smo
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    548779-60-8
  • Formula Weight
    454.12
  • Molecular Formula
    C20H12Cl4N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:9.08 mg/mL
  • SMILES
    C1=CC(=CC=C1NC(=O)C2=C(C=CC(=C2)Cl)Cl)NC(=O)C3=C(C=CC(=C3)Cl)Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Fan C W , Chen B , Franco I , et al. The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation[J]. Cell Chemical Biology, 2014, 21(12):1680-1689.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • GI-560192

    GI-560192 (RL-0070933) is a potent smo cilial modulator with an EC50 value of 0.02 μM. GI-560192 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway.

  • Glasdegib

    Glasdegib (PF-04449913) is a potent, orally bioavailable smoothened (SMO) inhibitor with IC50 of 5 nM in the Gli-luciferase reporter assays.

  • LEQ506

    LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.

Sign In Join Free