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IHR-1
CAS No. 548779-60-8
IHR-1( —— )
Catalog No. M24536 CAS No. 548779-60-8
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
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| 2MG | 28 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 73 | In Stock |
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| 25MG | 133 | In Stock |
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| 50MG | 200 | In Stock |
|
| 100MG | 300 | In Stock |
|
| 200MG | 431 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIHR-1
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NoteResearch use only, not for human use.
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Brief DescriptionIHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
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DescriptionIHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayWnt/Notch/Hedgehog
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TargetSmoothened (Smo)
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RecptorSmo
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Research Area——
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Indication——
Chemical Information
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CAS Number548779-60-8
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Formula Weight454.12
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Molecular FormulaC20H12Cl4N2O2
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Purity>98% (HPLC)
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SolubilityDMSO:9.08 mg/mL
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SMILESC1=CC(=CC=C1NC(=O)C2=C(C=CC(=C2)Cl)Cl)NC(=O)C3=C(C=CC(=C3)Cl)Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Fan C W , Chen B , Franco I , et al. The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation[J]. Cell Chemical Biology, 2014, 21(12):1680-1689.
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