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Home - Products - Chromatin/Epigenetic - Histone Demethylase - PFI-90

PFI-90

CAS No. 53995-62-3

PFI-90( 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide )

Catalog No. M24526 CAS No. 53995-62-3

PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 51 In Stock
25MG 32 In Stock
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Biological Information

  • Product Name
    PFI-90
  • Note
    Research use only, not for human use.
  • Brief Description
    PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity.
  • Description
    PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased.
  • In Vitro
    Western Blot Analysis Cell Line:RH4 and SCMC cells Concentration:3 μΜ Incubation Time:24 hours Result:Apoptosis increased in RH4 and SCMC cells.
  • In Vivo
    ——
  • Synonyms
    2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    RH4/RH30/OSA-CL/TC-32
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    53995-62-3
  • Formula Weight
    214.22
  • Molecular Formula
    C11H10N4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 40mg/mL?(186.72. mM);H2O: insoluble;Ethanol: 20mg/mL?(93.36 mM;?Need ultrasonic and warming)
  • SMILES
    O=C(C1=NC=CC=C1)NNC2=NC=CC=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.
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