Cart
sales@molnova.com
PFI-90
CAS No. 53995-62-3
PFI-90( 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide )
Catalog No. M24526 CAS No. 53995-62-3
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 51 | In Stock |
|
| 25MG | 32 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePFI-90
-
NoteResearch use only, not for human use.
-
Brief DescriptionPFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity.
-
DescriptionPFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased.
-
In VitroWestern Blot Analysis Cell Line:RH4 and SCMC cells Concentration:3 μΜ Incubation Time:24 hours Result:Apoptosis increased in RH4 and SCMC cells.
-
In Vivo——
-
Synonyms2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
-
PathwayChromatin/Epigenetic
-
TargetHistone Demethylase
-
RecptorRH4/RH30/OSA-CL/TC-32
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number53995-62-3
-
Formula Weight214.22
-
Molecular FormulaC11H10N4O
-
Purity>98% (HPLC)
-
SolubilityDMSO: 40mg/mL?(186.72. mM);H2O: insoluble;Ethanol: 20mg/mL?(93.36 mM;?Need ultrasonic and warming)
-
SMILESO=C(C1=NC=CC=C1)NNC2=NC=CC=C2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.
molnova catalog
related products
-
MRTX-1719
MRTX-1719 is a potent first-in-class selective inhibitor of the PRMT5/MTA complex, with an IC 50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells.
-
SNDX-5613
SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM).
-
Dot1L-IN-4
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor.
