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PFI-90
CAS No. 53995-62-3
PFI-90( 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide )
Catalog No. M24526 CAS No. 53995-62-3
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 31 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePFI-90
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NoteResearch use only, not for human use.
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Brief DescriptionPFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity.
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DescriptionPFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased.
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In VitroWestern Blot Analysis Cell Line:RH4 and SCMC cells Concentration:3 μΜ Incubation Time:24 hours Result:Apoptosis increased in RH4 and SCMC cells.
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In Vivo——
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Synonyms2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorRH4/RH30/OSA-CL/TC-32
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Research Area——
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Indication——
Chemical Information
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CAS Number53995-62-3
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Formula Weight214.22
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Molecular FormulaC11H10N4O
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Purity>98% (HPLC)
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SolubilityDMSO: 40mg/mL?(186.72. mM);H2O: insoluble;Ethanol: 20mg/mL?(93.36 mM;?Need ultrasonic and warming)
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SMILESO=C(C1=NC=CC=C1)NNC2=NC=CC=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.
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