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M?89
CAS No. 2363165-42-6
M?89( —— )
Catalog No. M24074 CAS No. 2363165-42-6
M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 356 | In Stock |
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| 5MG | 537 | In Stock |
|
| 10MG | 767 | In Stock |
|
| 25MG | 1161 | In Stock |
|
| 50MG | 1557 | In Stock |
|
| 100MG | 2115 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameM?89
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NoteResearch use only, not for human use.
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Brief DescriptionM-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.
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DescriptionM-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorMenin-MLL
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Research Area——
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Indication——
Chemical Information
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CAS Number2363165-42-6
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Formula Weight657.86
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Molecular FormulaC37H47N5O4S
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Purity>98% (HPLC)
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SolubilityDMSO:7 mg/mL?(10.64 mM;?Need ultrasonic)
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SMILESO=S(C1=CC=C(N2CC(CN3CCC([C@]4([C@H]5[C@H](OC(NC)=O)CCC5)CN(C)CC6=C4C=CC=C6)CC3)C2)C=C1)(C7=CC=NC=C7)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Aguilar A, et al. Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. J Med Chem. 2019 Jul 11;62(13):6015-6034.
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