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Home - Products - Chromatin/Epigenetic - Histone Demethylase - M?89

M?89

CAS No. 2363165-42-6

M?89( —— )

Catalog No. M24074 CAS No. 2363165-42-6

M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 568 In Stock
5MG 407 In Stock
10MG 561 In Stock
25MG 825 In Stock
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Biological Information

  • Product Name
    M?89
  • Note
    Research use only, not for human use.
  • Brief Description
    M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.
  • Description
    M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    Menin-MLL
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2363165-42-6
  • Formula Weight
    657.86
  • Molecular Formula
    C37H47N5O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:7 mg/mL?(10.64 mM;?Need ultrasonic)
  • SMILES
    O=S(C1=CC=C(N2CC(CN3CCC([C@]4([C@H]5[C@H](OC(NC)=O)CCC5)CN(C)CC6=C4C=CC=C6)CC3)C2)C=C1)(C7=CC=NC=C7)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Aguilar A, et al. Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. J Med Chem. 2019 Jul 11;62(13):6015-6034.
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