M?89

CAS No. 2363165-42-6

M?89( —— )

Catalog No. M24074 CAS No. 2363165-42-6

M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 568 In Stock
5MG 407 In Stock
10MG 561 In Stock
25MG 825 In Stock
50MG 1097 In Stock
100MG 1516 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    M?89
  • Note
    Research use only, not for human use.
  • Brief Description
    M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.
  • Description
    M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    Menin-MLL
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2363165-42-6
  • Formula Weight
    657.86
  • Molecular Formula
    C37H47N5O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:7 mg/mL?(10.64 mM;?Need ultrasonic)
  • SMILES
    O=S(C1=CC=C(N2CC(CN3CCC([C@]4([C@H]5[C@H](OC(NC)=O)CCC5)CN(C)CC6=C4C=CC=C6)CC3)C2)C=C1)(C7=CC=NC=C7)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Aguilar A, et al. Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. J Med Chem. 2019 Jul 11;62(13):6015-6034.
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