Cart
sales@molnova.com
M?89
CAS No. 2363165-42-6
M?89( —— )
Catalog No. M24074 CAS No. 2363165-42-6
M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 356 | In Stock |
|
| 5MG | 537 | In Stock |
|
| 10MG | 767 | In Stock |
|
| 25MG | 1161 | In Stock |
|
| 50MG | 1557 | In Stock |
|
| 100MG | 2115 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameM?89
-
NoteResearch use only, not for human use.
-
Brief DescriptionM-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.
-
DescriptionM-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetHistone Demethylase
-
RecptorMenin-MLL
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2363165-42-6
-
Formula Weight657.86
-
Molecular FormulaC37H47N5O4S
-
Purity>98% (HPLC)
-
SolubilityDMSO:7 mg/mL?(10.64 mM;?Need ultrasonic)
-
SMILESO=S(C1=CC=C(N2CC(CN3CCC([C@]4([C@H]5[C@H](OC(NC)=O)CCC5)CN(C)CC6=C4C=CC=C6)CC3)C2)C=C1)(C7=CC=NC=C7)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Aguilar A, et al. Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. J Med Chem. 2019 Jul 11;62(13):6015-6034.
molnova catalog
related products
-
LSD1-IN-32
LSD1-IN-32 is a potent, reversible lysine specific demethylase 1 (LSD1) inhibitor with biochemical IC50 of 83 nM, Kd of 32 nM, cell EC50 of 0.67 uM.
-
CPI-455
A potent, specific histone demethylase pan-KDM5 inhibitor with biochemical IC50 of 10, 3 and 14 nM for KDM5A, KDM5B and KDM5C, respectively.
-
KDOAM-25
KDOAM-25 (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family(JARID1) inhibitor.
