Cart
sales@molnova.com
SMI-4a
CAS No. 327033-36-3
SMI-4a( SMI-4a )
Catalog No. M18425 CAS No. 327033-36-3
TCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
|
| 5MG | 45 | In Stock |
|
| 10MG | 67 | In Stock |
|
| 25MG | 120 | In Stock |
|
| 50MG | 210 | In Stock |
|
| 100MG | 315 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSMI-4a
-
NoteResearch use only, not for human use.
-
Brief DescriptionTCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).
-
DescriptionTCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).
-
In Vitro——
-
In Vivo——
-
SynonymsSMI-4a
-
PathwayMAPK/ERK Signaling
-
TargetERK
-
RecptorPim 1| Pim 2
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number327033-36-3
-
Formula Weight273.23
-
Molecular FormulaC11H6F3NO2S
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 100 mg/mL; 365.99 mM
-
SMILESc1cc(cc(c1)C(F)(F)F)/C=C/1\C(=O)NC(=O)S1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Lin YW, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 ;115(4):824-33.
molnova catalog
related products
-
ISRIB (trans-isomer)
ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM.
-
Astex ERK inhibitor ...
Astex ERK inhibitor X is a novel potent ERK1/2 inhibitor that inhibits ERK catalytic activity with IC50 of 3 nM in TRK kinase assays.
-
Asperulosidic acid
Asperulosidic acid has anti-tumor, anti-oxidant, and anti-inflammatory activities.ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways.
