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SMI-4a
CAS No. 327033-36-3
SMI-4a( SMI-4a )
Catalog No. M18425 CAS No. 327033-36-3
TCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
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| 5MG | 45 | In Stock |
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| 10MG | 67 | In Stock |
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| 25MG | 120 | In Stock |
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| 50MG | 210 | In Stock |
|
| 100MG | 315 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSMI-4a
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NoteResearch use only, not for human use.
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Brief DescriptionTCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).
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DescriptionTCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).
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In Vitro——
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In Vivo——
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SynonymsSMI-4a
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PathwayMAPK/ERK Signaling
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TargetERK
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RecptorPim 1| Pim 2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number327033-36-3
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Formula Weight273.23
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Molecular FormulaC11H6F3NO2S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL; 365.99 mM
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SMILESc1cc(cc(c1)C(F)(F)F)/C=C/1\C(=O)NC(=O)S1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lin YW, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 ;115(4):824-33.
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