Marein

Research use only, not for human use.

Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway.

Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for preventing/counteracting diabetic encephalopathy.

Marein (0-1000 μM; 24 h) inhibits HDAC activity and TNFα-induced NF-κB activation with IC50 values of 100 and ＞200 μM, respectively.Marein (1.25-40 μM; 24 h) promotes glucose uptake in HepG2 cells.Marein (5-10 μM; 24 h) promotes GLUT1 translocation from intercellular vesicles to the plasma membrane, increases hepatic glycogen content and down-regulates expression levels of G6Pase and PEPCK in HepG2 cells.Marein (5-10 μM; 24 h) stimulates 2-NBDG uptake, and it can be reduced by STO-609 and compound C which is a inhibitor of AMPK.Marein (0-40 μM; 24 h) affects the cytotoxicity of MG in PC12 cells. Western Blot Analysis Cell Line:HepG2 cell line Concentration:5 and 10 μM Incubation Time:24 hours Result:Increased GLUT1 translocation to plasma membrane and decreased the phosphorylation level of AS160 and GSK-3β in HepG2 cells.Western Blot Analysis Cell Line:HepG2 cell line Concentration:10 μM Incubation Time:0-10 hours Result:Time- and dose-dependently induced phosphorylation of AMPK and Akt in HepG2 cells.Cell Viability Assay Cell Line:PC12 cell line Concentration:0-40 μM Incubation Time:24 hours Result:Prevened MG-induced loss of viability in PC12 cells.Apoptosis Analysis Cell Line:PC12 cell line Concentration:5-10 μM Incubation Time:30 min Result:Protected PC12 cells from MG-induced apoptosis.Western Blot AnalysisCell Line:PC12 cell line Concentration:5-10 μM Incubation Time:30 min Result:Increased phospho-AMPKα (Thr172) in PC12 cells.

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Cytoskeleton/Cell Adhesion Molecules

Akt

Akt|AMPK|GLUT

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535-96-6

450.4

C21H22O11

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (55.51 mM)

C1=CC(=C(C=C1/C=C/C(=O)C2=C(C(=C(C=C2)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)O)O)O

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(-20℃)

With Ice Pack

≥ 2 years