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Topovale
CAS No. 500214-53-9
Topovale( Topoval | ARC 111 | ARC111 | ARC-111 )
Catalog No. M24459 CAS No. 500214-53-9
Topovale is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 170 | In Stock |
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| 10MG | 242 | In Stock |
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| 25MG | 437 | In Stock |
|
| 50MG | 629 | In Stock |
|
| 100MG | 895 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTopovale
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NoteResearch use only, not for human use.
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Brief DescriptionTopovale is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha.
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DescriptionTopovale is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells.
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In Vitro——
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In Vivo——
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SynonymsTopoval | ARC 111 | ARC111 | ARC-111
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PathwayCell Cycle/DNA Damage
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TargetTopoisomerase
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Recptortopoisomerase I
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Research Area——
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Indication——
Chemical Information
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CAS Number500214-53-9
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Formula Weight421.45
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Molecular FormulaC23H23N3O5
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESCOC1=C(OC)C=C(C(N(CCN(C)C)C2=C3C=NC4=C2C=C(OCO5)C5=C4)=O)C3=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zhou W, Dai Z, Chen Y, Wang H, Yuan Z. High-Dimensional descriptor selection and computational QSAR modeling for antitumor activity of ARC-111 analogues Based on Support Vector Regression (SVR). Int J Mol Sci. 2012;13(1):1161-72. doi: 10.3390/ijms13011161. PubMed PMID: 22312310; PubMed Central PMCID: PMC3269744.
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