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YUM70
CAS No. 423145-35-1
YUM70( —— )
Catalog No. M24387 CAS No. 423145-35-1
YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 92 | In Stock |
|
| 5MG | 84 | In Stock |
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| 10MG | 130 | In Stock |
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| 25MG | 264 | In Stock |
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| 50MG | 381 | In Stock |
|
| 100MG | 542 | In Stock |
|
| 200MG | 734 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameYUM70
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NoteResearch use only, not for human use.
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Brief DescriptionYUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein).
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DescriptionYUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.
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In VitroWestern Blot Analysis Cell Line:MIA PaCa-2, PANC-1 cells Concentration:0.1, 1, 2.5, 5, 10 μM Incubation Time:2, 4, 8, 24, 48 hours Result:Increased the protein levels of FAM129A, DDIT3, CHAC-1, DDIT4, UPP1, and GRP78 in a dose- and time-dependent manner.
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In VivoAnimal Model:8-week old female NCr nude mice were injected with MIA PaCa-2 cells Dosage:30 mg/kg Administration:I.p. 5 days a week for 7 weeks Result:Observed a significant tumor growth delay with no significant change in body weight during the course of treatment.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetGPR
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RecptorGRP78
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Research Area——
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Indication——
Chemical Information
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CAS Number423145-35-1
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Formula Weight398.84
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Molecular FormulaC21H19ClN2O4
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL?(250.73 mM;?Need ultrasonic)
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SMILESO=C(CCC)NC(C1=CC=C2C(OCO2)=C1)C(C=C(Cl)C3=C4N=CC=C3)=C4O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Samanta S, et, al. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2;canres.1540.2020.
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