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PD146176
CAS No. 4079-26-9
PD146176( NSC168807 )
Catalog No. M24370 CAS No. 4079-26-9
PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 43 | In Stock |
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| 5MG | 39 | In Stock |
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| 10MG | 70 | In Stock |
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| 25MG | 141 | In Stock |
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| 50MG | 256 | In Stock |
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| 100MG | 448 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePD146176
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NoteResearch use only, not for human use.
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Brief DescriptionPD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
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DescriptionPD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
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In Vitro——
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In VivoAnimal Model:Triple transgenic (3xTg) mice Dosage:80 mg/kg Administration:Chowing; 12 weeks Result:Significantly lower amyloid beta levels and deposition, less tau neuropathology, increased synaptic integrity, and autophagy activation.
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SynonymsNSC168807
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PathwayAutophagy
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TargetAutophagy
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Recptor15-LO|Autophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number4079-26-9
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Formula Weight237.32
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Molecular FormulaC15H11NS
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Purity>98% (HPLC)
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SolubilityDMSO:25 mg/mL (105.34 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
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SMILESC1C2=C(C3=CC=CC=C3S1)NC4=CC=CC=C24
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Autogramin-2
Autogramin-2 potently inhibits?autophagy?induced by either starvation with IC50 of 0.27 μM, and inhibits mTORC1 (Rapamycin; IC50:0.14 μM)
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LYN-1604 2HCl 221675...
LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.?LYN-1604, to be the best candidate for a ULK1 agonist.?LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.?LYN-1604 has potential for good therapeutic effects on TNBC by targeting ULK1-modulated cell death in vivo.
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AUTEN-67
A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively.
