PD146176( NSC168807 )

Catalog No. M24370 CAS No. 4079-26-9

PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.

Purity : >98% (HPLC)

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Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	43	In Stock
5MG	39	In Stock
10MG	70	In Stock
25MG	141	In Stock
50MG	256	In Stock
100MG	448	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

PD146176
Note

Research use only, not for human use.
Brief Description

PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
Description

PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
In Vitro

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In Vivo

Animal Model:Triple transgenic (3xTg) mice Dosage:80 mg/kg Administration:Chowing; 12 weeks Result:Significantly lower amyloid beta levels and deposition, less tau neuropathology, increased synaptic integrity, and autophagy activation.
Synonyms

NSC168807
Pathway

Autophagy
Target

Autophagy
Recptor

15-LO|Autophagy
Research Area

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Indication

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Chemical Information

CAS Number

4079-26-9
Formula Weight

237.32
Molecular Formula

C15H11NS
Purity

>98% (HPLC)
Solubility

DMSO:25 mg/mL (105.34 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
SMILES

C1C2=C(C3=CC=CC=C3S1)NC4=CC=CC=C24
Chemical Name

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Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Bocan TM, et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit [published correction appears in Atherosclerosis 1998 Jul;139(1):201]. Atherosclerosis. 1998;136(2):203-216.

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