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ONO-AE3-208
CAS No. 402473-54-5
ONO-AE3-208( AE 3-208 )
Catalog No. M24362 CAS No. 402473-54-5
ONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 61 | In Stock |
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| 2MG | 33 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 88 | In Stock |
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| 25MG | 151 | In Stock |
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| 50MG | 219 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameONO-AE3-208
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NoteResearch use only, not for human use.
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Brief DescriptionONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
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DescriptionONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
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In VitroONO-AE3-208 surpresses the in vitro cell invasion and migration in a dose-dependent manner without affecting cell proliferation. ONO-AE3-208 abolisheS CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid (AA) causeS dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208.
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In VivoONO-AE3-208 surpresses the in vivo bone metastasis of PC3 cells in mice. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls.
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SynonymsAE 3-208
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PathwayGPCR/G Protein
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TargetProstaglandin Receptor
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RecptorEP4
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Research Area——
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Indication——
Chemical Information
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CAS Number402473-54-5
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Formula Weight404.43
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Molecular FormulaC24H21FN2O3
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Purity>98% (HPLC)
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SolubilityDMSO:40 mg/mL (98.9 mM);Water: Insoluble
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SMILESCC(C(Nc1c(CCCC(O)=O)ccc(C#N)c1)=O)c(c1ccccc11)ccc1F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Xu S, et al. An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer. Cell Biochem Biophys. 2014 Apr 18.
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