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GI 254023X
CAS No. 260264-93-5
GI 254023X( —— )
Catalog No. M24165 CAS No. 260264-93-5
GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 164 | In Stock |
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| 10MG | 222 | In Stock |
|
| 25MG | 430 | In Stock |
|
| 50MG | 644 | In Stock |
|
| 100MG | 888 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGI 254023X
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NoteResearch use only, not for human use.
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Brief DescriptionGI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE).
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DescriptionGI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). GI254023X can remarkably inhibit the proliferation and induce the apoptosis of H929 cells. Its mechanism may be associated with inbihition of Notch1 activation.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetMMP
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RecptorMMP-9| ADAM10
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Research Area——
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Indication——
Chemical Information
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CAS Number260264-93-5
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Formula Weight391.5
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Molecular FormulaC21H33N3O4
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (255.43 mM; Need ultrasonic)
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SMILESO=C(N[C@H](C(NC)=O)C(C)(C)C)[C@@H]([C@@H](N(C=O)O)C)CCCC1=CC=CC=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Verena V. Metz, et al. Induction of RAGE Shedding by Activation of G Protein-Coupled Receptors. PLoS One. 2012.
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