BDTX-189( —— )

Catalog No. M24111 CAS No. 2414572-47-5

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Datasheet

HNMR

HPLC

MSDS

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Product Name

BDTX-189
Note

Research use only, not for human use.
Brief Description

BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively). BDTX-189 exhibits anticancer activity.
Description

BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively). BDTX-189 exhibits anticancer activity.
In Vitro

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In Vivo

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Synonyms

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Pathway

Tyrosine Kinase
Target

BTK
Recptor

BLK|EGFR|HER2|RIPK2
Research Area

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Indication

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CAS Number

2414572-47-5
Formula Weight

561.03
Molecular Formula

C29H29ClN6O4
Purity

>98% (HPLC)
Solubility

DMSO:41.67 mg/mL (74.27 mM; Need ultrasonic)
SMILES

C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)OCCN5CCOCC5
Chemical Name

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1.Elizabeth Buck, et al. BDTX-189, a Potent and Selective Inhibitor of Allosteric EGFR and HER2 Oncogenic Mutations.

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