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Autogramin-2

CAS No. 2375541-45-8

Autogramin-2( tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate )

Catalog No. M24090 CAS No. 2375541-45-8

Autogramin-2 potently inhibits autophagy induced by either starvation with IC50 of 0.27 μM, and inhibits mTORC1 (Rapamycin; IC50:0.14 μM)

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 205 In Stock
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Biological Information

  • Product Name
    Autogramin-2
  • Note
    Research use only, not for human use.
  • Brief Description
    Autogramin-2 potently inhibits autophagy induced by either starvation with IC50 of 0.27 μM, and inhibits mTORC1 (Rapamycin; IC50:0.14 μM)
  • Description
    Autogramin-2 potently inhibits autophagy induced by either starvation with IC50 of 0.27 μM, and inhibits mTORC1 (Rapamycin; IC50:0.14 μM)
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2375541-45-8
  • Formula Weight
    417.52
  • Molecular Formula
    C21H27N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:83.33 mg/mL?(199.58 mM;?Need ultrasonic)
  • SMILES
    O=C(N1CCC2=C(SC(NC(C3=CC=C(OC(C)C)C=C3)=O)=N2)C1)OC(C)(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Laraia L, et al. The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis. Nat Chem Biol. 2019 Jul;15(7):710-720.
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