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Mito-LND
CAS No. 2361564-49-8
Mito-LND( Mito-Loidamine )
Catalog No. M24071 CAS No. 2361564-49-8
Mito-LND is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 236 | In Stock |
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| 5MG | 161 | In Stock |
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| 10MG | 269 | In Stock |
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| 25MG | 446 | In Stock |
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| 50MG | 598 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMito-LND
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NoteResearch use only, not for human use.
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Brief DescriptionMito-LND is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
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DescriptionMito-LND is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
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In VitroMito-LND blocks lung cancer growth, migration, and invasion. Mito-LND inhibits cell growth of H2030BrM3 and A549 cells with IC50 values of 0.74 μM and 0.69?μM, respectively.Mito-LND inhibits mitochondrial complex I and II activities with IC50 values of 1.2 μM and 2.4?μM, respectively in H2030BrM3 cells. Mito-LND (1?μM) increases ROS generation in H2030BrM3 lung cancer cells. Mito-LND potently induces mitochondrial ROS generation in H2030BrM3 lung cancer cells.Mito-LND (2?μM) decreases the levels of phosphorylated AKT. Mito-LND also decreases the phosphorylation of P70S6K and other energy-sensing proteins in both the parental and metastatic lung cancer cell lines, indicating that Mito-LND specifically downregulates mTOR signaling.
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In VivoMito-LND (7.5?μmol/kg; oral gavage; 5 days per week; for 3 consecutive weeks) treatment markedly enhanced potency against both lung cancer progression and metastasis. Mito-LND also decreases the rate of growth of A549 tumor xenografts.Mito-LND treatment shows a marked decrease in lung cancer brain metastasis in NOD/SCID mice bearing H2030BrM3 cells. Animal Model:Athymic nude mice (5 weeks) injected with H2030BrM3 cells Dosage:7.5?μmol/kg Administration:Oral gavage; 5 days per week; for 3 consecutive weeks Result:Significantly decreased tumor progression.
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SynonymsMito-Loidamine
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PathwayOthers
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TargetOther Targets
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Recptoroxidative phosphorylation (OXPHOS)
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Research Area——
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Indication——
Chemical Information
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CAS Number2361564-49-8
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Formula Weight801.62
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Molecular FormulaC43H45BrCl2N3OP
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Purity>98% (HPLC)
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SolubilityDMSO:45mg/ml(56.14mM; need ultrasonic)
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SMILESO=C(NCCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C4=NN(CC5=CC=C(Cl)C=C5Cl)C6=C4C=CC=C6.[Br-]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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(E)-dec-3-enoic acid
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PAR-3 (1-6) amide (m...
SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)
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gamma-Tocotrienol
gamma-Tocotrienol is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant.
