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DDO-5936
CAS No. 2355377-13-6
DDO-5936( —— )
Catalog No. M24068 CAS No. 2355377-13-6
DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 110 | In Stock |
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| 10MG | 192 | In Stock |
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| 25MG | 417 | In Stock |
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| 50MG | 615 | In Stock |
|
| 100MG | 876 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDDO-5936
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NoteResearch use only, not for human use.
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Brief DescriptionDDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
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DescriptionDDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
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In VitroDDO-5936 is a Hsp90-Cdc37 PPI inhibitor with potency and specificity through binding to a critical site on Hsp90 involving Glu47.
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In VivoDDO-5936 (0~80 mg/kg; p.o.) shows effect at the high dose group.DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 high dose groups show that tumor cells in the xenografts decreased significantly. DDO-5936 shows limited oral efficiency. Animal Model:Mice Dosage:0~80 mg/kg Administration:P.o.Result:Showed a moderate effect at the high dose group.
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSP90
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Research Area——
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Indication——
Chemical Information
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CAS Number2355377-13-6
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Formula Weight495.59
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Molecular FormulaC25H29N5O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 12.5 mg/mL (25.22 mM)
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SMILESO=C(O)CN(C1=CC=C(NC2=NC(N3CCCC3)=NC=C2)C=C1)S(=O)(C4=C(C)C=C(C)C=C4C)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer[J]. Journal of medicinal chemistry, 63(3):1281-1297.
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