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LY3405105
CAS No. 2326428-25-3
LY3405105( —— )
Catalog No. M24064 CAS No. 2326428-25-3
1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester is a novel CDK7 inhibitors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 93 | In Stock |
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| 10MG | 149 | In Stock |
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| 25MG | 282 | In Stock |
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| 50MG | 442 | In Stock |
|
| 100MG | 631 | In Stock |
|
| 200MG | 888 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLY3405105
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NoteResearch use only, not for human use.
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Brief Description1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester is a novel CDK7 inhibitors.
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Description1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester is a novel CDK7 inhibitors.
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In VitroCDK7-IN-4 (compound I) exhibits significant inhibitory activity against NCI-H446, SNU-16, HCC1806, A2780, MCF7, HCT116, and NCI-H460 cells, with IC50 values of 0.01419, 0,02312, 0.02553, 0.02651, 0.03201, 0.04601, and 0.0479, respectively.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK7
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Research Area——
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Indication——
Chemical Information
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CAS Number2326428-25-3
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Formula Weight497.64
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Molecular FormulaC26H39N7O3
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESO=C(N1CCC(NC2=CC(C)=NC3=C(C(C)C)C=NN23)CC1)OC4CN(C(/C=C/CN(C)C)=O)CC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Trilaciclib hydrochl...
Trilaciclib hydrochloride is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).Incubation with Trilaciclib hydrochloride (G1T28) for 24 hours can induce a strong G1 cell cycle arrest (time=0). Cells have re-entered the cell cycle and demonstrate cell-cycle kinetics similar to untreated control cells By 16 hours after Trilaciclib hydrochloride washout.
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ML133 HCl
ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.
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SEL120-34A hydrochlo...
SEL120-34A is an ATP-competitive, selective, orally active CDK8 inhibitor that inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50 of 4.4 nM and 10.4 nM, respectively.
