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Dimaprit dihydrochloride

CAS No. 23256-33-9

Dimaprit dihydrochloride( —— )

Catalog No. M24062 CAS No. 23256-33-9

Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Dimaprit dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion.
  • Description
    Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion.
  • In Vitro
    Dimaprit has less than 0.0001% the activity of histamine on H1-receptors.Dimaprit (0.1 nM-100 μM) inhibits nNOS concentration dependently with an IC50 of 49±14?μM.
  • In Vivo
    Dimaprit stimulates gastric acid secretion in rats (1.25 μM/kg/min; rapid i.v. injection), cats (2-64 μM/h; i.v.) and dogs (1-100 nM/kg/min; i.v.).Dimaprit (0.01-1 μM/kg; i.v. at intervals of 5 min) causes dose-dependent falls in blood pressure in cats. Dimaprit (1-100 nM; intra-arterial injection) causes vasodilatation in the femoral vascular bed, and it (1 μM/kg; bolus or intravenous injection) has no effect on heart rate.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    H2 receptor|nNOS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    23256-33-9
  • Formula Weight
    234.19
  • Molecular Formula
    C6H15N3S·2HCl
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:<23.42mg/ml
  • SMILES
    NC(SCCCN(C)C)=N.[H]Cl.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Parsons ME, et, al. Dimaprit -(S-[3-(N,N-dimethylamino)prophyl]isothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology. Agents Actions. 1977 Mar; 7(1): 31-7.
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