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Dimaprit dihydrochloride
CAS No. 23256-33-9
Dimaprit dihydrochloride( —— )
Catalog No. M24062 CAS No. 23256-33-9
Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 28 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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Biological Information
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Product NameDimaprit dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionDimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion.
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DescriptionDimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion.
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In VitroDimaprit has less than 0.0001% the activity of histamine on H1-receptors.Dimaprit (0.1 nM-100 μM) inhibits nNOS concentration dependently with an IC50 of 49±14?μM.
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In VivoDimaprit stimulates gastric acid secretion in rats (1.25 μM/kg/min; rapid i.v. injection), cats (2-64 μM/h; i.v.) and dogs (1-100 nM/kg/min; i.v.).Dimaprit (0.01-1 μM/kg; i.v. at intervals of 5 min) causes dose-dependent falls in blood pressure in cats. Dimaprit (1-100 nM; intra-arterial injection) causes vasodilatation in the femoral vascular bed, and it (1 μM/kg; bolus or intravenous injection) has no effect on heart rate.
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Synonyms——
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorH2 receptor|nNOS
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Research Area——
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Indication——
Chemical Information
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CAS Number23256-33-9
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Formula Weight234.19
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Molecular FormulaC6H15N3S·2HCl
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Purity>98% (HPLC)
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SolubilityH2O:<23.42mg/ml
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SMILESNC(SCCCN(C)C)=N.[H]Cl.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Parsons ME, et, al. Dimaprit -(S-[3-(N,N-dimethylamino)prophyl]isothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology. Agents Actions. 1977 Mar; 7(1): 31-7.
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