Cart
sales@molnova.com
BRM/BRG1 ATP Inhibitor-1
CAS No. 2270879-17-7
BRM/BRG1 ATP Inhibitor-1( —— )
Catalog No. M24032 CAS No. 2270879-17-7
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s<0.005 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 466 | In Stock |
|
| 5MG | 432 | In Stock |
|
| 10MG | 649 | In Stock |
|
| 25MG | 1121 | In Stock |
|
| 50MG | 1609 | In Stock |
|
| 100MG | 2260 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBRM/BRG1 ATP Inhibitor-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionBRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s<0.005 μM).
-
DescriptionBRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s<0.005 μM).
-
In VitroCell Proliferation Assay Cell Line:SKMEL5 melanoma cells and SBC-5 small cell carcinoma Concentration:0-10 μM Incubation Time:5 days Result:Inhibited the proliferation of SKMEL5 cells with an AAC50 (absolute AC50) value of 0.004 μM and of SBC-5 cells with the AAC50 more than 10 μM.
-
In VivoAnimal Model:Female athymic nude mice with RERF-LC-AI tumor xenografts Dosage:7.5 mg/kg, 20 mg/kg Administration:Oral administration; everyday; 3 weeks Result:Inhibited tumor growth by 21% and 55% at doses of 7.5 mg/kg and 20 mg/kg, respectively.Inhibited KRT80 expression by up to 90% at 20 mg/kg for 7 hours after administration.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorBRM/BRG1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2270879-17-7
-
Formula Weight318.27
-
Molecular FormulaC11H9F3N4O2S
-
Purity>98% (HPLC)
-
SolubilityDMSO:250 mg/mL (785.50 mM; Need ultrasonic)
-
SMILESO=C(NC1=CC(F)=NC=C1CO)NC2=CC(C(F)F)=NS2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172
molnova catalog
related products
-
9H-Carbazole, 1-meth...
9H-Carbazole, 1-methyl- is a marine derived natural products found in Tedania (Tedania) ignis.
-
RDR03785
The MIF Antagonist IV, RDR 03785 controls the biological activity of MIF. This small molecule/inhibitor is primarily used for Cell Structure applications.
-
L-allo-Threonine
Threonine is an essential amino acid in humans. It is abundant in human plasma particularly in newborns. Severe deficiency of threonine causes neurological dysfunction and lameness in experimental animals. Threonine is an immunostimulant which promotes the growth of thymus gland. It also can probably promote cell immune defense function.
