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BRM/BRG1 ATP Inhibitor-1
CAS No. 2270879-17-7
BRM/BRG1 ATP Inhibitor-1( —— )
Catalog No. M24032 CAS No. 2270879-17-7
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s<0.005 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 466 | In Stock |
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| 5MG | 432 | In Stock |
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| 10MG | 649 | In Stock |
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| 25MG | 1121 | In Stock |
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| 50MG | 1609 | In Stock |
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| 100MG | 2260 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBRM/BRG1 ATP Inhibitor-1
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NoteResearch use only, not for human use.
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Brief DescriptionBRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s<0.005 μM).
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DescriptionBRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s<0.005 μM).
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In VitroCell Proliferation Assay Cell Line:SKMEL5 melanoma cells and SBC-5 small cell carcinoma Concentration:0-10 μM Incubation Time:5 days Result:Inhibited the proliferation of SKMEL5 cells with an AAC50 (absolute AC50) value of 0.004 μM and of SBC-5 cells with the AAC50 more than 10 μM.
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In VivoAnimal Model:Female athymic nude mice with RERF-LC-AI tumor xenografts Dosage:7.5 mg/kg, 20 mg/kg Administration:Oral administration; everyday; 3 weeks Result:Inhibited tumor growth by 21% and 55% at doses of 7.5 mg/kg and 20 mg/kg, respectively.Inhibited KRT80 expression by up to 90% at 20 mg/kg for 7 hours after administration.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorBRM/BRG1
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Research Area——
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Indication——
Chemical Information
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CAS Number2270879-17-7
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Formula Weight318.27
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Molecular FormulaC11H9F3N4O2S
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (785.50 mM; Need ultrasonic)
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SMILESO=C(NC1=CC(F)=NC=C1CO)NC2=CC(C(F)F)=NS2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172
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