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CD73-IN-4
CAS No. 2216764-29-1
CD73-IN-4( —— )
Catalog No. M24001 CAS No. 2216764-29-1
CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 245 | In Stock |
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| 5MG | 242 | In Stock |
|
| 10MG | 392 | In Stock |
|
| 25MG | 701 | In Stock |
|
| 50MG | 918 | In Stock |
|
| 100MG | 1293 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCD73-IN-4
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NoteResearch use only, not for human use.
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Brief DescriptionCD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor.
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DescriptionCD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor.
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In VitroCD73-IN-4 (compound 4a) exhibits excellent potency against soluble hCD73 (IC50 = 0.86 nM) and soluble mouse CD73 (mCD73; IC50 = 3.0 nM), CHO cells overexpressing hCD73 (IC50 = 2.6 nM) or mCD73 (IC50 = 13 nM), and the human ovary cancer cell line SKOV-3 (IC50 = 0.55 nM). It exhibits excellent selectivity (IC50 > 10?000 nM) against CD39, A2aR, and NTPDase2, 3, and 8.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorCD73
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Research Area——
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Indication——
Chemical Information
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CAS Number2216764-29-1
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Formula Weight463.81
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Molecular FormulaC16H23ClN5O7P
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL?(265.19 mM;?Need ultrasonic)
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SMILESO[C@H]1[C@H](N2N=CC3=C(NC4CCCC4)N=C(Cl)N=C32)O[C@H](COCP(O)(O)=O)[C@H]1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ehesan U Sharif , et al. Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors. J Med Chem. 2021 Jan 5.
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