CD73-IN-4( —— )

Catalog No. M24001 CAS No. 2216764-29-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

CD73-IN-4
Note

Research use only, not for human use.
Brief Description

CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor.
Description

CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor.
In Vitro

CD73-IN-4 (compound 4a) exhibits excellent potency against soluble hCD73 (IC50 = 0.86 nM) and soluble mouse CD73 (mCD73; IC50 = 3.0 nM), CHO cells overexpressing hCD73 (IC50 = 2.6 nM) or mCD73 (IC50 = 13 nM), and the human ovary cancer cell line SKOV-3 (IC50 = 0.55 nM). It exhibits excellent selectivity (IC50 > 10?000 nM) against CD39, A2aR, and NTPDase2, 3, and 8.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

CD73
Research Area

——
Indication

——

CAS Number

2216764-29-1
Formula Weight

463.81
Molecular Formula

C16H23ClN5O7P
Purity

>98% (HPLC)
Solubility

DMSO:125 mg/mL?(265.19 mM;?Need ultrasonic)
SMILES

O[C@H]1[C@H](N2N=CC3=C(NC4CCCC4)N=C(Cl)N=C32)O[C@H](COCP(O)(O)=O)[C@H]1O
Chemical Name

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1.Ehesan U Sharif , et al. Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors. J Med Chem. 2021 Jan 5.

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