SU0268

Research use only, not for human use.

SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.

SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.

Cell Viability Assay Cell Line:A549 shGFP and shMTH1 (2000 cells per well).Concentration:0.1 μM, 0.5 μM, 1 μM, 2.5 μM, 5 μM, 7.5 μM, 10 μM.Incubation Time:24 or 48 h.Result:The shGFP cells were more susceptible to OGG1 inhibition via increasing SU0268 doses than the shMTH1 cells, especially at the 48 time-point.

Animal Model:Anesthetized C57BL/6N mice.Dosage:10 mg/kg.Administration:Intranasally treated.Result:Significantly inhibits inflammatory responses and mitigates P. aeruginosa infection.

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Others

Other Targets

8-oxoguanine DNA glycosylase 1 (OGG1)

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2210228-45-6

475.56

C26H25N3O4S

>98% (HPLC)

DMSO:100 mg/mL (210.28 mM; Need ultrasonic)

O=C(C1=CC(C2=CC=C(S(=O)(NC3=CC4=C(C=C3)CCCN4C(C5CC5)=O)=O)C=C2)=CC=C1)N

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(-20℃)

With Ice Pack

≥ 2 years