IACS-13909

Research use only, not for human use.

IACS-13909, a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.

IACS-13909, a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.

Cell Proliferation Assay Cell Line:Wild-type SHP2 and KYSE-520 cells Concentration:10 nM, 100 nM, 1 μM, 10 μM Incubation Time:14 days Result:Potently suppressed the cell proliferation. Western Blot Analysis Cell Line:Wild-type SHP2 and KYSE-520 cellsConcentration:1 μM, 5 μM Incubation Time:2 hours Result:Potently suppressed pERK and pMEK levels.

Animal Model:NSG mice (20-28 g) injected with KYSE-520 cells Dosage:70 mg/kg Administration:Oral administration; daily; for 21 days Result:Potently suppressed tumor growth in mice.

BBP-398 | IACS 13909

Metabolic Enzyme/Protease

Phospholipase

SHP-2

——

——

2160546-07-4

377.27

C17H18Cl2N6

>98% (HPLC)

DMSO:9 mg/mL?(23.86 mM;?Need ultrasonic)

NC1(C)CCN(C2=CN=C3C(NN=C3C4=CC=CC(Cl)=C4Cl)=N2)CC1

——

(-20℃)

With Ice Pack

≥ 2 years