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CAY10650
CAS No. 1233706-88-1
CAY10650( —— )
Catalog No. M23410 CAS No. 1233706-88-1
CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 121 | In Stock |
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| 5MG | 117 | In Stock |
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| 10MG | 176 | In Stock |
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| 25MG | 353 | In Stock |
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| 50MG | 483 | In Stock |
|
| 100MG | 641 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCAY10650
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NoteResearch use only, not for human use.
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Brief DescriptionCAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).
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DescriptionCAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).
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In VitroCAY10650 (12 nM; 30 min; neutrophils) inhibits the expression of the phosphorylated cPLA2-α (p-cPLA2-α) in cells.CAY10650 (12 nM; 2 h; neutrophils) inhibits PGE2 release in neutrophils. Western Blot Analysis Cell Line: Neutrophils Concentration:12 nM Incubation Time:30 minutes Result:Inhibited cPLA2-α and inhibited the expression of the p-cPLA2-α.Western Blot Analysis Cell Line:Neutrophils Concentration:12 nM Incubation Time:2 hours Result:Inhibited the PGE2 secretion and inhibited PGE2 realease.
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In VivoCAY10650 (50 μg/5 μL; Inject with topical eye-drop; Chinese hamsters) relieves acanthamoeba keratitis in vivo.. Animal Model:Chinese hamsters with infected with parasite-laden contact lensesDosage:50 μg/5 μL Administration:Inject with topical eye-drop under the contact lens; three times a day for 6 days and topically on days 7 to 20 postinfection Result:Reduced the severity of the keratitis and hasten the onset of resolution.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhospholipase
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RecptorcPLA2α
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Research Area——
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Indication——
Chemical Information
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CAS Number1233706-88-1
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Formula Weight471.5
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Molecular FormulaC28H25NO6
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Purity>98% (HPLC)
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SolubilityDMSO:40 mg/mL (84.84 mM)
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SMILESO=C(C1=CC2=C(N(CC(COC3=CC=C(OC4=CC=CC=C4)C=C3)=O)C=C2C(C(C)C)=O)C=C1)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tripathi T, et al. Role of phospholipase A 2(PLA2) inhibitors in attenuating apoptosis of the corneal epithelial cells and mitigation of Acanthamoeba keratitis. Exp Eye Res. 2013 Aug;113:182-91.
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