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Angoline
CAS No. 21080-31-9
Angoline( 6-Methoxyldihydrochelerythrine )
Catalog No. M23956 CAS No. 21080-31-9
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 133 | In Stock |
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| 10MG | 195 | In Stock |
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| 25MG | 327 | In Stock |
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| 50MG | 484 | In Stock |
|
| 100MG | 701 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAngoline
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NoteResearch use only, not for human use.
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Brief DescriptionAngoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM).
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DescriptionAngoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
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In VitroWestern Blot Analysis Cell Line:HepG2/STAT3 cell lineConcentration:0, 1, 10, 30 and 100 μM Incubation Time:2 hours Result:Inhibited IL-6-induced phosphorylation of STAT3 in HepG2/STAT3 cells.Cell Proliferation Assay Cell Line:MDA-MB-231, H4 and HepG2 cell lines Concentration:0-100 μM Incubation Time:72 hours Result:Inhibited proliferation of MDA-MB-231, H4 and HepG2 cells with IC50 values of 3.32, 4.72 and 3.14 μM, respectively.
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In Vivo——
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Synonyms6-Methoxyldihydrochelerythrine
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PathwayApoptosis
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TargetIL Receptor
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RecptorIL-6|STAT3
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Research Area——
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Indication——
Chemical Information
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CAS Number21080-31-9
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Formula Weight379.41
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Molecular FormulaC22H21NO5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20.83 mg/mL (54.90 mM)
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SMILESCN(C1OC)c2c(cc3OCOc3c3)c3ccc2-c(cc2)c1c(OC)c2OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Ganoderic acid A
Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1.
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Caulophyllogenin
Caulophyllogenin is a partial PPARγ agonist (EC50?=?12.6?μM) derived from the stem bark of Kalopanax pictus (Araliaceae).
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Ilexgenin A
Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis MerrIlexgenin A (IA), a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr.treatment with IA attenuated atherosclerosis in high-fat diet-induced apolipoprotein E deficient mice via a series of effects involving regulation of lipid parameters, decrease of atherosclerosis-related indexes, inhibition of inflammatory cytokines secretion and pathological changes of main organs.?
