Cart
sales@molnova.com
Home - Products - Microbiology/Virology - HBV - Vebicorvir

Vebicorvir

CAS No. 2090064-66-5

Vebicorvir( ABI-H0731 )

Catalog No. M23939 CAS No. 2090064-66-5

Vebicorvir is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 149 In Stock
10MG 239 In Stock
25MG 487 In Stock
50MG 593 In Stock
100MG 844 In Stock
200MG 1143 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Vebicorvir
  • Note
    Research use only, not for human use.
  • Brief Description
    Vebicorvir is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.
  • Description
    Vebicorvir is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.
  • In Vitro
    Vebicorvir (ABI-H0731) demonstrates inhibition of pgRNA, HBeAg, and HBsAg production, with EC50s of 2.68?μM, 4.95?μM, and 7.30?μM, respectively.Vebicorvir (ABI-H0731) is an inhibitor of pgRNA encapsidation and rcDNA synthesis.
  • In Vivo
    After i.v. administration, the drug rapidly distributes and decayes in a biphasic manner in all species tested. Plasma clearance values of ABI-H0731 were 8.05, 10.1, 14.7, and 4.86?ml/min/kg, representing 9, 16, 47, and 11% of liver blood flow, in mouse, rat, dog, and monkey, respectively.
  • Synonyms
    ABI-H0731
  • Pathway
    Microbiology/Virology
  • Target
    HBV
  • Recptor
    HBV DNA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2090064-66-5
  • Formula Weight
    467.44
  • Molecular Formula
    C19H12F3N3O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (213.93 mM)
  • SMILES
    O=C(c(cc1)cc(NC(c2c3cccc2)=O)c1S3(=O)=O)NCc1cnc(C(F)(F)F)s1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Huang Q, Cai D, Yan R, Li L, Zong Y, Guo L, Mercier A, Zhou Y, Tang A, Henne K, Colonno R. Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01463-20.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • HBV-IN-37

    HBV-IN-37 is an HBV inhibitor with an EC50 value of 10 μM and can be used for hepatitis B disease-related research.

  • Canocapavir

    Canocapavir (ZM-H1505R) is a novel orally available HBV coat protein modulator with antiviral activity that induces conformational changes in the linker region of the HBV core protein, and can be used for the treatment of hepatitis B virus.

  • AT-130

    AT-130 is a potent inhibitor of HBV capsid assembly, inhibits wild-type HBV replication with IC50 of 2.4 uM.

Sign In Join Free