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EACC

CAS No. 864941-31-1

EACC( —— )

Catalog No. M26188 CAS No. 864941-31-1

EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion.

Purity : >98% (HPLC)

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Biological Information

Product Name

EACC
Note

Research use only, not for human use.
Brief Description

EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion.
Description

EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. EACC is a reversible autophagy inhibitor.(In Vitro):EACC inhibits autophagy by preventing SNARE Stx17 loading on autophagosomes. EACC does not affect RABs, tethers, and lysosomal SNARE but prevents their interaction with LC3 and Stx17.EACC blocks autophagosome-lysosome fusion but does not affect endo-lysosomal function.
In Vitro

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In Vivo

——
Synonyms

——
Pathway

Autophagy
Target

Autophagy
Recptor

——
Research Area

——
Indication

——

Chemical Information

CAS Number

864941-31-1
Formula Weight

369.37
Molecular Formula

C13H11N3O6S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 16.88 mg/mL (45.70 mM)
SMILES

CCOC(=O)NC(=O)c1ccsc1NC(=O)c1ccc(s1)[N+]([O-])=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Yue L, Liu YJ. Mechanism of AMPPD Chemiluminescence in a Different Voice. J Chem Theory Comput. 2013 May 14;9(5):2300-12.

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