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Lanraplenib

CAS No. 1800046-95-0

Lanraplenib( GS-9876 )

Catalog No. M23810 CAS No. 1800046-95-0

Lanraplenib is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 91 In Stock
10MG 153 In Stock
25MG 275 In Stock
50MG 408 In Stock
100MG 600 In Stock
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Biological Information

  • Product Name
    Lanraplenib
  • Note
    Research use only, not for human use.
  • Brief Description
    Lanraplenib is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.
  • Description
    Lanraplenib is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GS-9876
  • Pathway
    Angiogenesis
  • Target
    Syk
  • Recptor
    SYK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1800046-95-0
  • Formula Weight
    443.5
  • Molecular Formula
    C23H25N9O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:41.67 mg/mL (93.96 mM; Need ultrasonic)
  • SMILES
    C1CN(CCN1C2COC2)C3=CC=C(C=C3)NC4=NC(=CN5C4=NC=C5)C6=CN=CC(=N6)N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Di Paolo J, et al. FRI0049 Preclinical Characterization of GS-9876, A Novel, Oral SYK Inhibitor That Shows Efficacy in Multiple Established Rat Models of Collagen-Induced Arthritis.Annals of the Rheumatic Diseases 2016;75:443-444.
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