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GNE-131
CAS No. 1629063-81-5
GNE-131( —— )
Catalog No. M23727 CAS No. 1629063-81-5
GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 282 | In Stock |
|
| 5MG | 264 | In Stock |
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| 10MG | 376 | In Stock |
|
| 25MG | 630 | In Stock |
|
| 50MG | 862 | In Stock |
|
| 100MG | 1144 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGNE-131
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NoteResearch use only, not for human use.
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Brief DescriptionGNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
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DescriptionGNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
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In VitroGNE-131 (Compound 13) shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 with an IC50 of 0.003±0.001 μM. GNE-131 shows excellent potency, good in vitro metabolic stability.
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In VivoGNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorNav1.7 channel
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Research Area——
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Indication——
Chemical Information
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CAS Number1629063-81-5
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Formula Weight442.57
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Molecular FormulaC23H30N4O3S
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Purity>98% (HPLC)
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SolubilityDMSO:120 mg/mL (271.14 mM; Need ultrasonic)
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SMILESO=S(C1CC1)(NC2=NN=C3C=C(OCC45CC6CC(C5)CC(C6)C4)C(C7CC7)=CN32)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Focken T, et al. Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain. J Med Chem. 2018 Jun 14;61(11):4810-4831.
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