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Mps1-IN-3
CAS No. 1609584-72-6
Mps1-IN-3( —— )
Catalog No. M23708 CAS No. 1609584-72-6
Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 59 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 80 | In Stock |
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| 25MG | 153 | In Stock |
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| 50MG | 263 | In Stock |
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| 100MG | 397 | In Stock |
|
| 200MG | 556 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMps1-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionMps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
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DescriptionMps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
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In VitroMps1-IN-3 is a potent MPS1 kinase inhibitor, with an IC50 of 50 nM. Mps1-IN-3 inhibits the proliferation of U251 glioblastoma cells with an IC50 of appr 5 μM. Mps1-IN-3 (2 μM) can completely abrogates checkpoint.
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In VivoMps1-IN-3 (2 mg/kg, i.v.) sensitizes glioblastoma cells in murine tumor models, with prolonged survival and no toxicity.
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetKinesin
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RecptorMps1
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Research Area——
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Indication——
Chemical Information
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CAS Number1609584-72-6
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Formula Weight537.63
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Molecular FormulaC26H31N7O4S
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Purity>98% (HPLC)
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SolubilityDMSO:5 mM
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SMILESO=S(C1=C(NC2=NC(NC3=CC=C(N4CCC(O)CC4)C=C3OC)=NC5=C2N=CN5)C=CC=C1)(C(C)C)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tannous BA, et al. Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs. J Natl Cancer Inst. 2013 Sep 4;105(17):1322-31.
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