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Mps1-IN-3

CAS No. 1609584-72-6

Mps1-IN-3( —— )

Catalog No. M23708 CAS No. 1609584-72-6

Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 59 In Stock
2MG 29 In Stock
5MG 49 In Stock
10MG 80 In Stock
25MG 153 In Stock
50MG 263 In Stock
100MG 397 In Stock
200MG 556 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Mps1-IN-3
  • Note
    Research use only, not for human use.
  • Brief Description
    Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
  • Description
    Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
  • In Vitro
    Mps1-IN-3 is a potent MPS1 kinase inhibitor, with an IC50 of 50 nM. Mps1-IN-3 inhibits the proliferation of U251 glioblastoma cells with an IC50 of appr 5 μM. Mps1-IN-3 (2 μM) can completely abrogates checkpoint.
  • In Vivo
    Mps1-IN-3 (2 mg/kg, i.v.) sensitizes glioblastoma cells in murine tumor models, with prolonged survival and no toxicity.
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Kinesin
  • Recptor
    Mps1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1609584-72-6
  • Formula Weight
    537.63
  • Molecular Formula
    C26H31N7O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:5 mM
  • SMILES
    O=S(C1=C(NC2=NC(NC3=CC=C(N4CCC(O)CC4)C=C3OC)=NC5=C2N=CN5)C=CC=C1)(C(C)C)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Tannous BA, et al. Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs. J Natl Cancer Inst. 2013 Sep 4;105(17):1322-31.
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