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Pitstop 2
CAS No. 1419320-73-2
Pitstop 2( —— )
Catalog No. M23573 CAS No. 1419320-73-2
Pitstop 2 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential for anti-cancer research.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 84 | In Stock |
|
| 5MG | 76 | In Stock |
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| 10MG | 132 | In Stock |
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| 25MG | 275 | In Stock |
|
| 50MG | 423 | In Stock |
|
| 100MG | 625 | In Stock |
|
| 200MG | 890 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePitstop 2
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NoteResearch use only, not for human use.
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Brief DescriptionPitstop 2 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential for anti-cancer research.
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DescriptionPitstop 2 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential for anti-cancer research.
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In VitroPitstop 2 (20-40 μM; 30 min) inhibits the endocytosis of transferrin in J774A.1 macrophages and does not compromise cell viability.Pitstop 2 (20-40 μM; 30 min) does not affect the internalization of cholera toxin B in J774A.1 macrophages.Pitstop 2 (0.001-100 μM; 6 h) inhibits the mitotic spindle and impairs mitotic progression in HeLa cells.Pitstop 2 (1-30 μM; 24 h) induces apoptosis and inhibits cell growth in dividing cancer cells.Pitstop 2 (1-30 μM; 48 h) does not affect the growth and viability of non-tumourigenic NIH3T3 fibroblasts. Cell Viability Assay Cell Line:HeLa cells Concentration:1, 3, 10, 30 μM Incubation Time:24 hours Result:Reduced the total number of viable HeLa cells markedly in a dose-dependent manner.
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1419320-73-2
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Formula Weight473.36
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Molecular FormulaC20H13BrN2O3S2
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Purity>98% (HPLC)
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SolubilityDMSO : 62.5 mg/mL (132.03 mM; Need ultrasonic)
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SMILESO=S(C1=C2C=CC=CC2=CC=C1)(NC(S/C3=C\C4=CC=C(Br)C=C4)=NC3=O)=O.[(Z)]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Smith CM, et, al. Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Mol Cancer. 2013 Jan 17; 12:4.
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