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ML198

CAS No. 1380716-06-2

ML198( —— )

Catalog No. M23537 CAS No. 1380716-06-2

ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ML198
  • Note
    Research use only, not for human use.
  • Brief Description
    ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase.
  • Description
    ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecule treatment for patients suffering from Gaucher disease.
  • In Vitro
    ML198 is stable in D-PBS pH 7.4 at room temperature over 48 hr.ML198 increases translocation of GCase to the lysosome (20% cell translocation at 5 μM, compared to 5% of DMSO) in human fibroblasts.ML198 shows promising microsomal stability and Caco-2 permeability, with low water solubility.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Glucokinase
  • Recptor
    glucocerebrosidase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1380716-06-2
  • Formula Weight
    290.32
  • Molecular Formula
    C17H14N4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:Insoluble;Water:Insoluble
  • SMILES
    CC1=CC(=NC2=C(C=NN12)C(=O)NC3=CC=C(C=C3)C#C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Rogers S , Patnaik S , Schoenen F , et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase[M]. PubMed, 2010.
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