Propargyl-PEG3-acid( —— )

Catalog No. M23509 CAS No. 1347760-82-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Propargyl-PEG3-acid
Note

Research use only, not for human use.
Brief Description

Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne.
Description

Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA and Propargyl-PEG3-acid.
In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
In Vivo

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Synonyms

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Pathway

PROTACs
Target

PROTAC
Recptor

PEGs|Non-cleavable
Research Area

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Indication

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1.Farzam A, et al. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox Biol. 2020 Jan;28:101377.

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