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Avexitide

CAS No. 133514-43-9

Avexitide( Exendin (9-39) | Exendin-3 (9-39) amide )

Catalog No. M23488 CAS No. 133514-43-9

Avexitide (Exendin (9-39)) is a specific and competitive antagonist of glucagon-like peptide-1 (GLP-1) receptor.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Avexitide
  • Note
    Research use only, not for human use.
  • Brief Description
    Avexitide (Exendin (9-39)) is a specific and competitive antagonist of glucagon-like peptide-1 (GLP-1) receptor.
  • Description
    Avexitide (Exendin (9-39)) is a specific and competitive antagonist of glucagon-like peptide-1 (GLP-1) receptor.
  • In Vitro
    GLP-1 plays a role in the control of fasting glucose. Avexitide (Exendin (9-39)), a truncated form of the GLP-1 agonist exendin-4, is a specific GLP-1 receptor antagonist.
  • In Vivo
    Continuous subcutaneous infusion of Avexitide (Exendin (9-39)) significantly raises fasting blood glucose levels in SUR-1 -/- mice without affecting glucose tolerance.
  • Synonyms
    Exendin (9-39) | Exendin-3 (9-39) amide
  • Pathway
    GPCR/G Protein
  • Target
    Glucagon Receptor
  • Recptor
    GLP-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    133514-43-9
  • Formula Weight
    3369.76
  • Molecular Formula
    C149H234N40O47S
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : 49 mg/mL (14.54 mM; Need ultrasonic)
  • SMILES
    CC[C@H](C)[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](Cc1c[nH]c2c1cccc2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(NCC(NCC(N(CCC1)[C@@H]1C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@@H](C)C(N(CCC1)[C@@H]1C(N(CCC1)[C@@H]1C(N(CCC1)[C@@H]1C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](Cc1ccccc1)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCSC)NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Calabria AC, et al. GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital hyperinsulinism owing to inactivating mutations in the ATP-sensitive K+ channel. Diabetes. 2012 Oct;61(10):2585-91.
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