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LY-2940094

CAS No. 1307245-86-8

LY-2940094( —— )

Catalog No. M23461 CAS No. 1307245-86-8

LY-2940094 decreases ethanol self-administration in animal models.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LY-2940094
  • Note
    Research use only, not for human use.
  • Brief Description
    LY-2940094 decreases ethanol self-administration in animal models.
  • Description
    LY-2940094 decreases ethanol self-administration in animal models. LY-2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)Dosage:3, 10, or 30 mg/kg; 2-3 mL/kg Administration:Administered orally; daily; 4 days Result:Reduced homecage ethanol self-administration.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    NOP receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1307245-86-8
  • Formula Weight
    480.96
  • Molecular Formula
    C22H23ClF2N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:41.67 mg/mL (86.64 mM; Need ultrasonic)
  • SMILES
    Cc(c(CN(CC1)CCC1(c(s1)c2cc1Cl)OCC2(F)F)c1)nn1-c1ncccc1CO
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54.
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