Cart
sales@molnova.com
LY-2940094
CAS No. 1307245-86-8
LY-2940094( —— )
Catalog No. M23461 CAS No. 1307245-86-8
LY-2940094 decreases ethanol self-administration in animal models.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 180 | In Stock |
|
| 2MG | 103 | In Stock |
|
| 5MG | 158 | In Stock |
|
| 10MG | 274 | In Stock |
|
| 25MG | 542 | In Stock |
|
| 50MG | 762 | In Stock |
|
| 100MG | 1051 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLY-2940094
-
NoteResearch use only, not for human use.
-
Brief DescriptionLY-2940094 decreases ethanol self-administration in animal models.
-
DescriptionLY-2940094 decreases ethanol self-administration in animal models. LY-2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM).
-
In Vitro——
-
In VivoAnimal Model:Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)Dosage:3, 10, or 30 mg/kg; 2-3 mL/kg Administration:Administered orally; daily; 4 days Result:Reduced homecage ethanol self-administration.
-
Synonyms——
-
PathwayEndocrinology/Hormones
-
TargetOpioid Receptor
-
RecptorNOP receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1307245-86-8
-
Formula Weight480.96
-
Molecular FormulaC22H23ClF2N4O2S
-
Purity>98% (HPLC)
-
SolubilityDMSO:41.67 mg/mL (86.64 mM; Need ultrasonic)
-
SMILESCc(c(CN(CC1)CCC1(c(s1)c2cc1Cl)OCC2(F)F)c1)nn1-c1ncccc1CO
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54.
molnova catalog
related products
-
CTAP(TFA）
CTAP TFA is a potent, highly selective, and brain penetrant ?antagonist of μ-opioid receptor with IC50 of 3.5 nM.?It displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somatostatin receptors.
-
Meptazinol hydrochlo...
Meptazinol Hcl(WY-22811 Hcl) is a unique centrally active opioid analgesic.
-
β-Endorphin, equine
Endorphin Beta is A substance produced in the brain, especially in the pituitary gland, Endorphin Beta blocks the sensation of pain. Endorphin Beta is produced in response to pain, exercise, and other forms of stress. Endorphin Beta belongs to a group of chemicals called polypeptide hormones.
