Cart
sales@molnova.com
Home - Products - Endocrinology/Hormones - Opioid Receptor - SNC-80

SNC-80

CAS No. 156727-74-1

SNC-80( NIH-10815 )

Catalog No. M12237 CAS No. 156727-74-1

A highly selective, non-peptide agonist of the δ-opioid receptor (δ-OR) with IC50/Ki of 2.73/0.18 nM; displays >2,000-fold selectivity over the μ-opioid receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 32 In Stock
5MG 50 In Stock
10MG 92 In Stock
25MG 219 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SNC-80
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly selective, non-peptide agonist of the δ-opioid receptor (δ-OR) with IC50/Ki of 2.73/0.18 nM; displays >2,000-fold selectivity over the μ-opioid receptor.
  • Description
    A highly selective, non-peptide agonist of the δ-opioid receptor (δ-OR) with IC50/Ki of 2.73/0.18 nM; displays >2,000-fold selectivity over the μ-opioid receptor; selectively activates μ-δ heteromers to produce maximal antinociception.Pain Discontinued.
  • In Vitro
    SNC80 selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 exhibits substantially greater activity in cells coexpressing μ- and δ-opioid receptors than in cells either singly expressing δ-opioid receptors or coexpressing δ- and κ-opioid receptors.
  • In Vivo
    SNC80 (10 mg/kg; intraperitoneal injection; once; C57BL6/J mice) treatment significantly attenuated this allodynia caused by overuse of Sumatriptan. Animal Model:Male and female C57BL6/J mice (20-30g) injected with Sumatriptan Dosage:10 mg/kg Administration:Intraperitoneal injection; once Result:Significantly attenuated allodynia.
  • Synonyms
    NIH-10815
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    Opioid Receptor
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    156727-74-1
  • Formula Weight
    449.6
  • Molecular Formula
    C28H39N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (74.13 mM)
  • SMILES
    O=C(N(CC)CC)C1=CC=C([C@@H](N2[C@@H](C)CN(CC=C)[C@H](C)C2)C3=CC=CC(OC)=C3)C=C1
  • Chemical Name
    4-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethyl-benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Calderon SN, et al. J Med Chem. 1994 Jul 8;37(14):2125-8. 2. Bilsky EJ, et al. J Pharmacol Exp Ther. 1995 Apr;273(1):359-66. 3. Metcalf MD, et al. ACS Chem Neurosci. 2012 Jul 18;3(7):505-9.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • CTAP(TFA）

    CTAP TFA is a potent, highly selective, and brain penetrant ?antagonist of μ-opioid receptor with IC50 of 3.5 nM.?It displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somatostatin receptors.

  • Hemorphin-7

    Hemorphin-7 binds to the angiotensin IV receptor, triggering multiple effects including cellular proliferation and memory enhancement. Hemorphins are endogenous peptides belonging to the family of atypical opioid peptides released from hydrolyzed hemoglobin. Hemorphin-7 is investigated as a potential biomarker for breast cancer.

  • ML-184

    ML-184 is a potent synthetic agonist of GPR55 with EC50 of 0.26 μM.

Sign In Join Free