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SNC-80
CAS No. 156727-74-1
SNC-80( NIH-10815 )
Catalog No. M12237 CAS No. 156727-74-1
A highly selective, non-peptide agonist of the δ-opioid receptor (δ-OR) with IC50/Ki of 2.73/0.18 nM; displays >2,000-fold selectivity over the μ-opioid receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
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| 5MG | 50 | In Stock |
|
| 10MG | 92 | In Stock |
|
| 25MG | 219 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSNC-80
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NoteResearch use only, not for human use.
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Brief DescriptionA highly selective, non-peptide agonist of the δ-opioid receptor (δ-OR) with IC50/Ki of 2.73/0.18 nM; displays >2,000-fold selectivity over the μ-opioid receptor.
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DescriptionA highly selective, non-peptide agonist of the δ-opioid receptor (δ-OR) with IC50/Ki of 2.73/0.18 nM; displays >2,000-fold selectivity over the μ-opioid receptor; selectively activates μ-δ heteromers to produce maximal antinociception.Pain Discontinued.
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In VitroSNC80 selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 exhibits substantially greater activity in cells coexpressing μ- and δ-opioid receptors than in cells either singly expressing δ-opioid receptors or coexpressing δ- and κ-opioid receptors.
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In VivoSNC80 (10 mg/kg; intraperitoneal injection; once; C57BL6/J mice) treatment significantly attenuated this allodynia caused by overuse of Sumatriptan. Animal Model:Male and female C57BL6/J mice (20-30g) injected with Sumatriptan Dosage:10 mg/kg Administration:Intraperitoneal injection; once Result:Significantly attenuated allodynia.
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SynonymsNIH-10815
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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RecptorOpioid Receptor
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number156727-74-1
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Formula Weight449.6
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Molecular FormulaC28H39N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 33.33 mg/mL (74.13 mM)
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SMILESO=C(N(CC)CC)C1=CC=C([C@@H](N2[C@@H](C)CN(CC=C)[C@H](C)C2)C3=CC=CC(OC)=C3)C=C1
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Chemical Name4-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethyl-benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Calderon SN, et al. J Med Chem. 1994 Jul 8;37(14):2125-8.
2. Bilsky EJ, et al. J Pharmacol Exp Ther. 1995 Apr;273(1):359-66.
3. Metcalf MD, et al. ACS Chem Neurosci. 2012 Jul 18;3(7):505-9.
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