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NH2-PEG6-Boc
CAS No. 1286281-32-0
NH2-PEG6-Boc( —— )
Catalog No. M23449 CAS No. 1286281-32-0
NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 27 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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Biological Information
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Product NameNH2-PEG6-Boc
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NoteResearch use only, not for human use.
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Brief DescriptionNH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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DescriptionNH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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In Vivo——
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Synonyms——
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PathwayPROTACs
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TargetPROTAC
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RecptorPEGs|Alkyl/ether|Non-cleavable
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Research Area——
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Indication——
Chemical Information
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CAS Number1286281-32-0
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Formula Weight409.51
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Molecular FormulaC19H39NO8
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCN
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Foley CA, et al. Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay. ACS Chem Biol. 2020 Jan 17;15(1):290-295.
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