GNF179

Research use only, not for human use.

GNF179 is an optimized 8,8-dimethyl IP analog.

GNF179 is an optimized 8,8-dimethyl IP analog. It exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.

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Animal Model:Na?ve Balb/C mice infected with P. berghei Dosage:15 mg/kg Administration:Oral, single dose Result:Protected against an infectious P. berghei sporozoite.Animal Model:Na?ve Balb/C miceDosage:3 or 20 mg/kg Administration:IV or PO (Pharmacokinetic Analysis)Result: Pharmacokinetics of GNF179 in na?ve Balb/C mice.AUC, Area Under the Curve; T1/2, half life; CL, clearance; VSS, steady-state volume of distribution; C0, initial concentration; Cmax maximum concentration; F, fraction of dose absorbed; hrs, hours; nd, not determined.

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Microbiology/Virology

Parasite

Parasite

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1261114-01-5

427.9

C22H23ClFN5O

>98% (HPLC)

DMSO:120 mg/mL (280.44 mM)

CC(C)(c1nc(-c(cc2)ccc2F)c(Nc(cc2)ccc2Cl)n1CC1)N1C(CN)=O

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(-20℃)

With Ice Pack

≥ 2 years