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Balovaptan

CAS No. 1228088-30-9

Balovaptan( RG7314 )

Catalog No. M23402 CAS No. 1228088-30-9

Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 54 In Stock
10MG 87 In Stock
25MG 177 In Stock
50MG 286 In Stock
100MG 447 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    Balovaptan
  • Note
    Research use only, not for human use.
  • Brief Description
    Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist.
  • Description
    Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors. It is used for the research of autism.
  • In Vitro
    Balovaptan (RG7314) shows >30000-fold selectivity for hV1a over hV2 receptors, 9891-fold selectivity over hOTR (human oxytocin receptor).
  • In Vivo
    ——
  • Synonyms
    RG7314
  • Pathway
    GPCR/G Protein
  • Target
    Vasopressin Receptor
  • Recptor
    vasopressin receptor 1a
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1228088-30-9
  • Formula Weight
    409.91
  • Molecular Formula
    C22H24ClN5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:62.5 mg/mL (152.47 mM; Need ultrasonic)
  • SMILES
    CN1Cc(cc(cc2)Cl)c2-n2c(C(CC3)CCC3Oc3ncccc3)nnc2C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89.
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