Cart
sales@molnova.com
CDDO-dhTFEA
CAS No. 1191265-33-4
CDDO-dhTFEA( RTA dh404 )
Catalog No. M23361 CAS No. 1191265-33-4
CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 187 | In Stock |
|
| 2MG | 88 | In Stock |
|
| 5MG | 147 | In Stock |
|
| 10MG | 255 | In Stock |
|
| 25MG | 511 | In Stock |
|
| 50MG | 723 | In Stock |
|
| 100MG | 1014 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2018 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCDDO-dhTFEA
-
NoteResearch use only, not for human use.
-
Brief DescriptionCDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.
-
DescriptionCDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. It restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats.
-
In Vitro——
-
In Vivo——
-
SynonymsRTA dh404
-
PathwayApoptosis
-
TargetNF-κB
-
RecptorNF-κB|Nrf2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1191265-33-4
-
Formula Weight574.72
-
Molecular FormulaC33H45F3N2O3
-
Purity>98% (HPLC)
-
SolubilityDMSO:100 mg/mL (174.00 mM; Need ultrasonic)
-
SMILESC[C@@]12CC[C@@H]3[C@@]([C@H]1CC(=O)[C@H]4[C@]2(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)NCC(F)(F)F)C)(C=C(C(=O)C3(C)C)C#N)C
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease. Redox Biol. 2013 Oct 31;1:527-31.
molnova catalog
related products
-
Indole-3-carbinol
Indole-3-Carbinol is a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin。
-
Polyphyllin I
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels.
-
SR12343
SR12343 (SR-12343) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation.
