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MYLS22
CAS No. 306959-01-3
MYLS22( —— )
Catalog No. M23118 CAS No. 306959-01-3
MYLS22 is a first-in-class and selective optic atrophy 1 (OPA1) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 60 | In Stock |
|
| 2MG | 33 | In Stock |
|
| 5MG | 54 | In Stock |
|
| 10MG | 92 | In Stock |
|
| 25MG | 158 | In Stock |
|
| 50MG | 235 | In Stock |
|
| 100MG | 364 | In Stock |
|
| 200MG | 546 | In Stock |
|
| 500MG | 864 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMYLS22
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NoteResearch use only, not for human use.
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Brief DescriptionMYLS22 is a first-in-class and selective optic atrophy 1 (OPA1) inhibitor.
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DescriptionMYLS22 is a first-in-class and selective optic atrophy 1 (OPA1) inhibitor. MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene expression.
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In VitroWestern Blot Analysis Cell Line:MLE12 cells Concentration:10 nM Incubation Time:30 min Result:Increased the phosphorylation levels of RIPK3 and MLKL protein.
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In VivoAnimal Model:LPS‐induced ALI miceDosage:12.5 mg/kg Administration:i.p., 2 days Result:Increased lung inflammatory score, Tnf‐α and pro‐Il‐1β mRNA expression, and total IL‐1β or IL‐1β p17 protein expression.Increased the levels of RIPK3, MLKL protein, and their phosphorylation.Decreased the levels of SPC protein.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOPA1
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Research Area——
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Indication——
Chemical Information
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CAS Number306959-01-3
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Formula Weight443.52
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Molecular FormulaC??H??N?O?S
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Purity>98% (HPLC)
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SolubilityDMSO : 50 mg/mL (112.73 mM; ultrasonic and warming and heat to 60°C)
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Stéphanie Herkenne, et al. Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1. Cell Metab. 2020 May 5;31(5):987-1003.e8.
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