Pralmorelin acetate 158861-67-7(free base)

Research use only, not for human use.

Pralmorelin acetate stimulates growth hormone secretion.Pralmorelin acetate is an oral active synthetic peptide analogue of MEK. Pralmorelin acetate, an auxin releasing peptide/growth hormone secretory receptor agonist, can selectively stimulate ghrelin receptor and cause growth hormone release.

Pralmorelin acetate stimulates growth hormone secretion.Pralmorelin acetate is an oral active synthetic peptide analogue of MEK. Pralmorelin acetate, an auxin releasing peptide/growth hormone secretory receptor agonist, can selectively stimulate ghrelin receptor and cause growth hormone release. Pralmorelin has shown anti-inflammatory activity.An anti-inflammatory role for ghrelin (GHRP-2) in PKC-mediated inflammation of granulosa cells, at least in part, due to its inhibitory effect on PKC-induced activation of p38, JNK and NF-κB, possibly by targeting to MKP-1 and PP2A.An insulin tolerance test (ITT), CRH stimulation test, and GHRP-2 test on 47 patients suspected of having a hypothalamo-pituitary disorder were preformed. The results indicate that the GHRP-2 test may induce ACTH secretion from the pituitary gland through direct stimulation.

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GPCR/G Protein

GHSR

GHS-R

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938.08

C49H63N9O10

>98% (HPLC)

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CC(O)=O.NCCCC[C@@H](C(N)=O)NC([C@@H](CC1=CC=CC=C1)NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](C)NC([C@@H](CC4=CC=C5C=CC=CC5=C4)NC([C@@H](C)N)=O)=O)=O)=O)=O

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(-20℃)

With Ice Pack

≥ 2 years