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TMN355
CAS No. 1186372-20-2
TMN355( —— )
Catalog No. M22935 CAS No. 1186372-20-2
TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 2MG | 48 | In Stock |
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| 5MG | 77 | In Stock |
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| 10MG | 117 | In Stock |
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| 25MG | 235 | In Stock |
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| 50MG | 346 | In Stock |
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| 100MG | 510 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1088 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTMN355
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NoteResearch use only, not for human use.
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Brief DescriptionTMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.
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DescriptionTMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL. The expression of scavenger receptors expressed during differentiation process, CD36 and LOX-1 were decreased (p < 0.0001). Levels of extracellular cyclophilin A and other inflammatory cytokines such as TNF-α and MCP-1also significantly reduced. TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And cyclophilin A after 6 h of activation inhibited by TMN 355(1 μM).
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In VitroTMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And 1 μM TMN 355 inhibits cyclophilin A after 6 h of activation.Western Blot Analysis Cell Line:THP cell lines Concentration:0.5, 1, 2.5, 5 and 10 μM Incubation Time:3, 6 and 9 hours Result:Resulted in 75.9% reduction of cyclophilin A protein expression.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorcyclophilin A
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Research Area——
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Indication——
Chemical Information
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CAS Number1186372-20-2
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Formula Weight380.8
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Molecular FormulaC21H14ClFN2O2
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Purity>98% (HPLC)
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SolubilityDMSO:31.25 mg/mL (82.06 mM; Need ultrasonic)
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SMILESO=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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FIDAS-5
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