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1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS No. 4004-05-1

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine( DOPE )

Catalog No. M22918 CAS No. 4004-05-1

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
  • Note
    Research use only, not for human use.
  • Brief Description
    1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.
  • Description
    1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.Each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent). With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effect on macrophages and DCs and Liposome-containing DOPE shows fusogenicity. LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    DOPE
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    4004-05-1
  • Formula Weight
    744.03
  • Molecular Formula
    C41H78NO8P
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:31.25 mg/mL (42.00 mM; Need ultrasonic)
  • SMILES
    O=P(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)(OCCN)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Uemura Y, et al. The efficiency of lipid nanoparticles with an original cationic lipid as a siRNA delivery system for macrophages and dendritic cells.Pharm Dev Technol.?2019 Mar;24(3):263-268.
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