Aromadendrin

Research use only, not for human use.

Aromadendrin is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activityAromadendrin, a flavonol, has been reported to possess a variety of pharmacological activities such as anti-inflammatory, antioxidant, and anti-diabetic properties.

Aromadendrin is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activityAromadendrin, a flavonol, has been reported to possess a variety of pharmacological activities such as anti-inflammatory, antioxidant, and anti-diabetic properties. Aromadendrin significantly suppressed LPS-induced excessive production of pro-inflammatory mediators such as nitric oxide (NO) and PGE2. In accordance, aromadendrin attenuated LPSinduced overexpression iNOS and COX-2. In addition, aromadendrin significantly suppressed LPS-induced degradation of IκB, which sequesters NF-κB in cytoplasm, consequently inhibiting the nuclear translocation of pro-inflammatory transcription factor NF- κB. Aromadendrin significantly attenuated LPS-induced activation of JNK, but not ERK and p38, in a concentration-dependent manner. Aromadendrin exhibits anti-inflammatory activity through the suppression of nuclear translocation of NF-κB and phosphorylation of JNK in LPS-stimulated RAW 264.7 macrophage cells.

Cell Proliferation Assay Cell Line:Normal synoviocyte cells; RA-FLS cells Concentration:0.3 μM, 3 μM, 30 μM, 300 μM Incubation Time:48 hours Result:Decreased the proliferation of RA-FLSs.Apoptosis Analysis Cell Line:RA-FLS cells Concentration:3 μM, 30 μM Incubation Time:48 hours Result:Induced apoptosis in RA-FLSs.Western Blot Analysis Cell Line:RA-FLS cells Concentration:3 μM, 30 μM Incubation Time:48 hours Result:Promoted Bax and Bad expression, increased the cleaved fragments of caspase-3, caspase-9 and cleaved PARP and inhibited Bcl-2 and Bcl-xL expression.

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Angiogenesis

Bcl-2

Bcl-2|Bcl-xL

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480-20-6

288.3

C15H12O6

>98% (HPLC)

DMSO:120 mg/mL (416.31 mM; Need ultrasonic); H2O:< 0.1 mg/mL (insoluble)

O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC=C(O)C=C3)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years