Cart
sales@molnova.com
Home - Products - Angiogenesis - Bcl-2 - BTSA1

BTSA1

CAS No. 314761-14-3

BTSA1( —— )

Catalog No. M19903 CAS No. 314761-14-3

BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 34 In Stock
5MG 58 In Stock
10MG 110 In Stock
25MG 178 In Stock
50MG 335 In Stock
100MG 500 In Stock
500MG 1098 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    BTSA1
  • Note
    Research use only, not for human use.
  • Brief Description
    BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.
  • Description
    BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.
  • In Vitro
    Cell Viability Assaysup>Cell Line:Human AML cell lines
  • In Vivo
    Animal Model:NOD-SCID IL2Rγ null (NSG) mice (6-8 weeks old) with THP-1 cells Dosage:10 mg/kg Administration:Intraperitoneal injection; every two days Result:Significantly increased survival when compared to vehicle-treated mice.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bax
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    314761-14-3
  • Formula Weight
    430.51
  • Molecular Formula
    C21H14N6OS2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 65 mg/mL
  • SMILES
    O=C1N(N=C(\C1=N/Nc1nccs1)c1ccccc1)c1nc(cs1)-c1ccccc1
  • Chemical Name
    1H-Pyrazole-45-dione 3-phenyl-1-(4-phenyl-2-thiazolyl)- 4-[2-(2-thiazolyl)hydrazone]

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Reyna DE et al. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 2017 Oct 9;32(4):490-505.e10.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • 17-Hydroxy sprengeri...

    17-Hydroxy sprengerinin C is a glycoside compound isolated from rhizomes of Polygonatum sibiricum with stronger anticancer activities.

  • Orobol

    Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibits anti-skin-aging and anti-obesity effects.

  • BCL6-IN-8

    BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface.

Sign In Join Free