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GR 125743
CAS No. 148547-33-5
GR 125743( —— )
Catalog No. M22737 CAS No. 148547-33-5
GR 125743 is a novel antagonist of 5-HT1B/1D receptor.GR-125743, a new radiolabelled derivative of a compound that exhibits selective antagonistic properties with respect to the serotonin human (h5-HT1D) and human (h5-HT1B) receptors. The compound has been characterized for its ability to label the cloned h5-HT1D and h5-HT1B receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 2MG | 48 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 116 | In Stock |
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| 25MG | 235 | In Stock |
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| 50MG | 343 | In Stock |
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| 100MG | 511 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGR 125743
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NoteResearch use only, not for human use.
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Brief DescriptionGR 125743 is a novel antagonist of 5-HT1B/1D receptor.GR-125743, a new radiolabelled derivative of a compound that exhibits selective antagonistic properties with respect to the serotonin human (h5-HT1D) and human (h5-HT1B) receptors. The compound has been characterized for its ability to label the cloned h5-HT1D and h5-HT1B receptors.
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DescriptionGR 125743 is a novel antagonist of 5-HT1B/1D receptor.GR-125743, a new radiolabelled derivative of a compound that exhibits selective antagonistic properties with respect to the serotonin human (h5-HT1D) and human (h5-HT1B) receptors. The compound has been characterized for its ability to label the cloned h5-HT1D and h5-HT1B receptors.
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In VitroGR 125743 has a Kd of 0.61 nM for h5-HT1B.
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In VivoGR 125743 (0.3 mg/kg; i.p.) produces significant decreases in extracellular 5-HT in the frontal cortex of the conscious guinea pig. Animal Model:Male Dunkin Hartley guinea-pigs (350-450 g)Dosage:0.3 mg/kg Administration:Intraperitoneal injection Result:Produced significant transient increases in extracellular 5-HT.
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT1B/1D
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Research Area——
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Indication——
Chemical Information
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CAS Number148547-33-5
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Formula Weight416.53
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Molecular FormulaC25H28N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (240.08 mM)
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SMILESCOc1ccc(NC(=O)c2ccc(c(C)c2)-c2ccncc2)cc1N1CCN(C)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. T Doménech, J Beleta, J M Palacios,et al.Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist.Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):328-34.
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