Cart
sales@molnova.com
Poziotinib hydrochloride
CAS No. 1429757-68-5
Poziotinib hydrochloride( NOV120101 hydrochloride,HM 781-36B hydrochloride )
Catalog No. M22736 CAS No. 1429757-68-5
Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
|
| 5MG | 29 | In Stock |
|
| 10MG | 43 | In Stock |
|
| 25MG | 73 | In Stock |
|
| 50MG | 107 | In Stock |
|
| 100MG | 160 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 398 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePoziotinib hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionPoziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.
-
DescriptionPoziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.
-
In Vitro——
-
In Vivo——
-
SynonymsNOV120101 hydrochloride,HM 781-36B hydrochloride
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorEGFR
-
Research AreaCancer
-
IndicationBreast Cancer; Gastric Cancer; Head and neck Cancer; Lung Cancer; Non-small cell lung Cancer
Chemical Information
-
CAS Number1429757-68-5
-
Formula Weight527.8
-
Molecular FormulaC23H22Cl3FN4O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCl.COc1cc2ncnc(Nc3ccc(Cl)c(Cl)c3F)c2cc1OC1CCN(CC1)C(=O)C=C
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Nam HJ, et al. Cancer Lett. 2011, 302(2), 155-165.
molnova catalog
related products
-
LDC4297
LDC4297 is a potent and selective CDK7 inhibitor.
-
PD 174265
PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.
-
JCN037
JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).
